Minerva Medica (rivista ) vol. Salvioli's diffusing vaccine (known by its Italian initials VDS, for vaccino diffondente Salvioli) was an Italian vaccine against tuberculosis used from 1948 until 1976, formulated by professor Gaetano Salvioli (1894–1982) of the University of Bologna.The VDS was for some decades the Italian competitor of the French BCG vaccine against tuberculosis. Objective: To determine the influence of past BCG vaccination on tuberculin sensitivity in tuberculosis contacts. In the area of Bologna (municipality and province) up to 80% of newborns were vaccinated. One took 150 cubic centimeters of milk to which were added 1 gram of peptone, 6 grams of potato starch and a peeled potato washed and in pieces. It was left, always in a bain-marie for about another 30 minutes. Se realizează tuturor nou-născuţilor cu greutatea mai mare de 2500 gr, începând din ziua 4-5 până la vârsta de 60 zile. – Acul trebuie să fie aproape paralel cu suprafaţa pielii şi se introduce uşor cu bizoul în sus, aproximativ 2 mm în stratul superficial al dermului. Creator and developer of the first anti-tuberculosis vaccination (the so-called "Maragliano Vaccine"), he was Senator of the Kingdom of Italy since 1900. [5], In the second post-war period, the spread of TB in Italy was still very high, but antituberculous vaccination was not mandatory. Conclusion: Este estudio sugiere que la edad de los contactos y el resultado de la baciloscopia de los casos índices constituyen determinantes importantes de la sensibilidad tuberculínica. The bibliography of the time indicates that from 1948 to 1970 the VDS was applied very widely in different parts of Italy. Ceux qui n'avaient pas de cicatrice n'ont eu aucune reponse au test. Approximately 50%, 30% and 20% of the contacts respectively had negative (0–4 mm), positive (5–14 mm) and strongly positive (15+ mm) Mantoux responses. La locul vaccinării rămâne o cicatrice denivelată fața de tegumentele din jur, la început de culoare violacee, apoi alb-sidefie cu diametrul de 5-6 mm și care constituie locul vaccinării. Risque attribuable au vaccin. La presencia de cicatriz BCG no parecía tener una influencia significativa sobre el grado de sensibilidad a la tuberculina. When Petragnani interrupted his studies and applications (because he was appointed in 1935 by Benito Mussolini, as Director General of Public Health), Professor Gaetano Salvioli continued his studies and applications. By continuing you agree to the use of cookies. Read about scars, including the different types, how and where they form and how they're treated. Attribuer une réponse Mantoux ‘positive’ à la vaccination BCG antérieure pourrait encourager à tort une impression d'immunité chez des contacts récemment exposés à des tuberculeux contagieux. Copyright © 1995 Published by Elsevier Ltd. https://doi.org/10.1016/0962-8479(95)90553-7. – seringă de 1ml cu ac intradermic, seringă 5 ml cu ac intramuscular – sterile 1-7 zile de la naștere - vaccinul de tip Calmette Guerin BCG - este un vaccin administrat pentru a preveni tuberculoza. Nu se aplică tratament local la nivelul reacției vaccinale. Estos hallazgos podrían llevar quizás a una revision de las directivas para el manejo de los contactos. Over the years there were several Italian centers (pediatric clinics, provincial consortia antitubercolari, headquarters of ONMI (Opera Nazionale Maternità Infanzia) that applied the "Italian-style vaccine" as they used to say at the time to distinguish it from the "French-style vaccine", the competitor BCG. Copyright © 2020 Elsevier B.V. or its licensors or contributors. [6] In the summer of 1958, however, he gave up the production of the vaccine because its 6th supply of 3000 pieces, turned out not to correspond to the protocol provided by Professor Gaetano Salvioli. [2], One dose for newborns consisted of "a single intradermal injection, carried out at about half of the palmar face of the forearm, is used to introduce into the newborn baby a dose N of lyophilized anti-tuberculosis vaccine consisting of human Koch [bK] bacilli and cattle killed rapidly by heat. Suspensia astfel obținută conține 0,10 mg bacili/ 0,1 ml și se utilizează cât mai curând ( dupa cel mult o oră ) fiind tot timpul protejată de lumina directă și de căldură. Adenopatiile mai mari de 10-15 mm şi adenitele supurate sunt reacţiiexcepţionale şi sunt provocate în majoritatea cazurilor, de, IDR pozitiv, tuberculoză activă, imunodeficienţe congenitale, SIDA, boli febrile, convalescenţa dupa boli infecțioase, Afectiuni dermatologice acute, leucemii, limfoame, boli maligne. In 1970 it was declared that about 100,000 vaccinations had been performed with positive results. The VDS was also applied abroad: in Osaka in Japan, Czechoslovakia, Poland, Kolwezi (now in the Democratic Republic of Congo). We filtered through sterile gauze in a graduated cylinder and we added to the filtrate 3% of glycerine and 4% of an aqueous solution to 2% of malachite. Unfortunately, tuberculosis also entered into the sanatorium, causing several victims. Vaccinul se administreaza strict intradermic, în partea postero-externă a braţului stâng, în treimea medie. The presence of a BCG scar was not found to significantly influence the degree of tuberculin sensitivity. ISM was, from 1894 to 1994, a non-profit institution entirely owned by the Municipality of Milan, with a plant in via Darwin in Milan. From 1959, until the decision of the Ministry of Health to officially adopt the BCG in Italy (art.1 of the Ministerial Decree of 25 June 1976), the production of VDS returned to the companies of Dr. Marino Golinelli. Attributing a ‘positive’ Mantoux response to past BCG vaccination may be encouraging a false sense of security in contacts recently exposed to an infectious case of tuberculosis. Results: In 1050 contacts of 96 cases of tuberculosis, BCG scars were noted in 76% of the contacts. Manifestations cliniques après la vaccination. The VDS, definitively standardized between 1948 and 1953 by Professor Gaetano Salvioli, originated first in the studies and vaccine products of Professor Edoardo Maragliano (1849–1940) [1] and Professor Giovanni Petragnani (1893–1969), physiologist and rector of the University of Siena. – Acul trebuie să fie vizibil prin epidermă în timpul introducerii. Papula dispare în aproximativ 30 de minute. După un interval de 8-10 săptămâni de la vaccinare se instalează alergia vaccinală.
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